{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"RNOOXKZJDRWUEI-INIZCTEOSA-N","prefName":"5F-MDMB-PINACA (5F-ADB)","symbol":"5F-MDMB-PINACA","iupacName":"methyl (S)-2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate","aliases":["5F-ADB","5F-MDMB-PINACA"],"cas":"1715016-75-3","pubchemCid":"118798967","chebiId":null,"smiles":"CC(C)(C)[C@@H](C(=O)OC)NC(=O)C1=NN(C2=CC=CC=C21)CCCCCF","molecularFormula":"C20H28FN3O3","molecularWeight":377.46,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/118798967"}},"classification":{"family":"scra","familyLabel":"Cannabinoide sintético (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origen (investigación farmacéutica → mercado ilícito)","summaryFr":"Indazol-3-carboxamida con cabeza tert-leucinato metiléster y cadena 5-fluoropentilo; SCRA de la oleada 3","originNote":"Mercado ilícito (origen académico desconocido)","discovered":"2014"},"pharmacology":{"summaryFr":"5F-MDMB-PINACA (5F-ADB) - indazol-3-carboxamida, cabeza tert-leucinato metiléster, cola 5-fluoropentilo. Caracterización por Banister et al. (ACS Chem Neurosci 2016): EC50 CB1 ≈ 0,59 nM. SCRA más frecuentemente incautado en Europa 2018-2020 (informes EUDA). La Decisión de Ejecución (UE) **2018/1485** amplía el control. La CND **62/8** (marzo de 2019) lo sitúa en el Anexo II del Convenio de 1971. Francia: **Arrêté (orden ministerial) del 31 de marzo de 2017** (NOR AFSP1710288A) - listado en el anexo IV incluso antes de la decisión de la UE.","receptorSummaryFr":"Agonista completo CB1 (EC50 ≈ 0,59 nM β-arrestina) - extremadamente potente","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":99,"reported":"EC50 ≈ 0,59 nM","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":90,"reported":null,"confidence":"low"}],"references":[{"label":"Banister · ACS Chem Neurosci 2016","pmid":"27421060","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/27421060/"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":20},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":15},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":60},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":45},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":99}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"controlled-named","scheduleLabel":"Estupefaciente: listado nominalmente","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"Decisión del Consejo (UE) 2018/1485","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Estupefaciente listado nominalmente","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Banister · ACS Chem Neurosci 2016","pmid":"27421060","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/27421060/"}],"meta":{"slug":"5f-mdmb-pinaca","url":"https://es.phytogrammes.com/wiki/5f-mdmb-pinaca","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}