{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"ZSSGCSINPVBLQD-UHFFFAOYSA-N","prefName":"ADB-FUBINACA","symbol":"ADB-FUBINACA","iupacName":"N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide","aliases":["ADB-F","AB-FUB-ADAMINA (incorrect)"],"cas":"1445583-51-6","pubchemCid":"70969086","chebiId":null,"smiles":"CC(C)(C)C(C(=O)N)NC(=O)C1=NN(C2=CC=CC=C21)CC3=CC=C(C=C3)F","molecularFormula":"C21H23FN4O2","molecularWeight":382.4,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/70969086"}},"classification":{"family":"scra","familyLabel":"Cannabinoide sintético (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origen (investigación farmacéutica → mercado ilícito)","summaryFr":"Indazol-3-carboxamida con cabeza tert-leucinato-amida y cola 4-fluorobencilo; desviado hacia el mercado ilícito a partir de 2013","originNote":"Patente Pfizer WO 2009/106980 (nunca comercializada)","discovered":"2009"},"pharmacology":{"summaryFr":"El ADB-FUBINACA pertenece a la patente Pfizer WO 2009/106980 (Buchler et al., 2009) - programa analgésico abandonado. Desviado hacia el mercado ilícito hacia 2013. Caracterización por Banister et al. (ACS Chem Neurosci 2015, PMID 25714476): CB1 EC50 ≈ 0,17 nM (beta-arrestina) - uno de los SCRA más potentes documentados. Múltiples oleadas de sobredosis: Misisipi 2015 (n ≈ 1000 casos), Florida 2017, varias regiones de Rusia. Francia: listado nominalmente por el **Arrêté (orden ministerial) del 5 de agosto de 2013** (NOR AFSP1318894A; JORFTEXT000027822624). UE: Delegado (UE) **2019/369**.","receptorSummaryFr":"Agonista completo CB1 (EC50 ≈ 0,17 nM beta-arrestina; ≈ 50× THC) - uno de los SCRA más potentes por beta-arrestina","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":99,"reported":"EC50 ≈ 0,17 nM","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":92,"reported":null,"confidence":"low"}],"references":[{"label":"Banister · ACS Chem Neurosci 2015","pmid":"25714476","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/25714476/"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":20},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":15},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":55},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":45},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":99}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"controlled-named","scheduleLabel":"Estupefaciente: listado nominalmente","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"Decisión marco + Delegado (UE) 2019/369","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Estupefaciente listado nominalmente","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Banister · ACS Chem Neurosci 2015","pmid":"25714476","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/25714476/"}],"meta":{"slug":"adb-fubinaca","url":"https://es.phytogrammes.com/wiki/adb-fubinaca","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}