{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"WVOLTBSCXRRQFR-DLBZAZTESA-N","prefName":"Ácido cannabidiólico","symbol":"CBDA","iupacName":"(1R,6R)-3-methyl-6-(prop-1-en-2-yl)-4-pentyl-2-(2,4-dihydroxybenzoyl)cyclohex-3-en-1-ol carboxylic acid","aliases":["Acide cannabidiolique","CBD-A"],"cas":"1244-58-2","pubchemCid":"160570","chebiId":null,"smiles":"CCCCCC1=CC(=C(C(=C1C(=O)O)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O","molecularFormula":"C22H30O4","molecularWeight":358.47,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/160570"}},"classification":{"family":"mineur","familyLabel":"Fitocannabinoide menor","origin":"natural","originLabel":"Naturel","structuralClassFr":null},"originSynthesis":{"heading":"Vía biosintética","summaryFr":"Forma ácida nativa del CBD en la planta cruda - pierde su grupo carboxilo para convertirse en CBD durante la descarboxilación térmica","originNote":"Planta (ácido)","discovered":"1955"},"pharmacology":{"summaryFr":"El CBDA es la forma ácida nativa del CBD tal como existe en la planta cruda, antes de la descarboxilación térmica. Al calentar la flor (combustión, vaporización, cocción al horno), el CBDA pierde su grupo carboxilo y se convierte en CBD - de ahí la confusión frecuente entre ambos. En forma no descarboxilada, el CBDA presenta una afinidad 5-HT1A varios cientos de veces superior a la del CBD, lo que lo convierte en un candidato serio frente a la náusea inducida por quimioterapia y la ansiedad aguda (trabajos de Bolognini, Rock y Parker, 2013). Conservación en frío, al abrigo de la luz. Administración típica: aceites « raw », zumo de hojas frescas, cápsulas de liberación prolongada.","receptorSummaryFr":"Inhibidor selectivo de la COX-2, agonista 5-HT1A (afinidad varios cientos de veces superior a la del CBD), modulador GPR55","binding":[{"target":"COX-2","efficacy":"antagonist","relativeActivity":70,"reported":null,"confidence":"low"},{"target":"5-HT1A","efficacy":"full_agonist","relativeActivity":90,"reported":null,"confidence":"low"},{"target":"GPR55","efficacy":"modulator","relativeActivity":45,"reported":null,"confidence":"low"}],"references":[{"label":"Bolognini · Br J Pharmacol 2013","pmid":"23488637","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/23488637/"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":65},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":55},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":40},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":35},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":30}],"doseRanges":null,"humanDataCharacterised":true},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":false,"bannerTextFr":null,"toxicologyFr":null},"legal":{"scheduleStatus":"industrial-exempt","scheduleLabel":"Excepción del cáñamo","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"Autorizado","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Autorizado","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Bolognini · Br J Pharmacol 2013","pmid":"23488637","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/23488637/"}],"meta":{"slug":"cbda","url":"https://es.phytogrammes.com/wiki/cbda","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":80,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}