{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"SEEZIOZEUUMJME-FOWTUZBSSA-N","prefName":"Ácido cannabigerólico","symbol":"CBGA","iupacName":null,"aliases":["CBG-A","Cannabigerolic acid"],"cas":"25555-57-1","pubchemCid":"6449999","chebiId":null,"smiles":"CCCCCC1=CC(=C(C(=C1C(=O)O)O)C/C=C(\\C)/CCC=C(C)C)O","molecularFormula":"C22H32O4","molecularWeight":360.49,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/6449999"}},"classification":{"family":"mineur","familyLabel":"Fitocannabinoide menor","origin":"natural","originLabel":"Naturel","structuralClassFr":null},"originSynthesis":{"heading":"Vía biosintética","summaryFr":"Primer cannabinoide formado en la planta - ácido olivetólico + GPP (geranil pirofosfato) → CBGA. Convertido después enzimáticamente en THCA, CBDA, CBCA según la variedad","originNote":"Planta (ácido precursor)","discovered":"1964"},"pharmacology":{"summaryFr":"El CBGA (ácido cannabigerólico) es el primer cannabinoide producido por la planta, a partir de ácido olivetólico y de geranil pirofosfato. Según el genotipo de la planta, el CBGA es convertido después por tres sintasas distintas en THCA, CBDA o CBCA - de ahí la expresión « cannabinoide madre ». Actividad PPARγ documentada (interés metabólico). En 2021, van Breemen et al. (J Nat Prod, PMID 35040332) publicaron una actividad in vitro contra la entrada del SARS-CoV-2 - resultado preliminar, sin validación clínica. Régimen francés: cannabis Tableau B.","receptorSummaryFr":"Actividad directa modesta sobre CB1/CB2; agonista PPARα/γ (de interés cardiometabólico); modulador GPR55","binding":[{"target":"CB1","efficacy":"modulator","relativeActivity":25,"reported":null,"confidence":"low"},{"target":"PPARγ","efficacy":"full_agonist","relativeActivity":65,"reported":null,"confidence":"low"},{"target":"GPR55","efficacy":"modulator","relativeActivity":35,"reported":null,"confidence":"low"}],"references":[{"label":"van Breemen · J Nat Prod 2022","pmid":"35040332","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/35040332/"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":50},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":60},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":30},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":35},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":30}],"doseRanges":null,"humanDataCharacterised":true},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":false,"bannerTextFr":null,"toxicologyFr":null},"legal":{"scheduleStatus":"industrial-exempt","scheduleLabel":"Excepción del cáñamo","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"Cannabis según el uso","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Régimen cannabis","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"van Breemen · J Nat Prod 2022","pmid":"35040332","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/35040332/"}],"meta":{"slug":"cbga","url":"https://es.phytogrammes.com/wiki/cbga","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":80,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}