{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"YJYIDZLGVYOPGU-XNTDXEJSSA-N","prefName":"Cannabigerovarina","symbol":"CBGV","iupacName":"2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-propylbenzene-1,3-diol","aliases":["cannabigérovarine","cannabigerovarin","CBGV","cannabigérivarine"],"cas":"55824-11-8","pubchemCid":"59444407","chebiId":null,"smiles":"CCCC1=CC(=C(C(=C1)O)C/C=C(\\C)/CCC=C(C)C)O","molecularFormula":"C19H28O2","molecularWeight":288.4,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/59444407"}},"classification":{"family":"principal","familyLabel":"Fitocannabinoide mayor","origin":"natural","originLabel":"Naturel","structuralClassFr":null},"originSynthesis":{"heading":"Vía biosintética","summaryFr":"Nace de la descarboxilación del ácido cannabigerovarínico (CBGVA), la rama « varina » (cadena propilo) de la biosíntesis cannabinoide. Formado en los tricomas glandulares, sirve de precursor de las formas propílicas como el THCV y el CBDV.","originNote":"Cáñamo (Cannabis sativa L.), sobre todo en los quimiotipos ricos en varinas.","discovered":""},"pharmacology":{"summaryFr":"El CBGV es el homólogo propílico del CBG: su cadena lateral solo cuenta con tres carbonos en lugar de cinco. No psicotrópico, nace de la descarboxilación del ácido cannabigerovarínico (CBGVA) y alimenta la rama « varina » de la planta, que conduce al THCV y al CBDV. Como el CBG, presenta una afinidad modesta por los receptores CB1 y CB2 e interactúa con los canales TRP; sus datos siguen siendo esencialmente preclínicos.","receptorSummaryFr":"Homólogo propilo del CBG: afinidad modesta por los receptores CB1 y CB2, e interacción con los canales TRP (en particular antagonismo de TRPM8), a semejanza de su homólogo pentilo. Molécula no psicotrópica.","binding":[{"target":"CB1","efficacy":"partial_agonist","relativeActivity":12,"reported":null,"confidence":"low"},{"target":"CB2","efficacy":"partial_agonist","relativeActivity":18,"reported":null,"confidence":"low"},{"target":"TRPM8","efficacy":"antagonist","relativeActivity":40,"reported":null,"confidence":"low"}],"references":[{"label":"PubChem CID 59444407 : Cannabigerovarin (identité, formule, InChIKey, IUPAC)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/59444407"},{"label":"PubChem : synonymes et identifiants (CID 59444407)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/59444407/synonyms/JSON"},{"label":"MedChemExpress : Cannabigerovarin (CBGV), fiche réactif","pmid":null,"doi":null,"url":"https://www.medchemexpress.com/cannabigerovarin.html"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":55},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":65},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":25},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":45},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":40}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"No listado","frScheduleStatus":"unscheduled","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No clasificado · regulado como ingrediente derivado del cáñamo (estatuto novel food según la forma)","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"No clasificado como estupefaciente · tolerado como cannabinoide minoritario (umbral de THC del cáñamo)","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"PubChem CID 59444407 : Cannabigerovarin (identité, formule, InChIKey, IUPAC)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/59444407"},{"label":"PubChem : synonymes et identifiants (CID 59444407)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/59444407/synonyms/JSON"},{"label":"MedChemExpress : Cannabigerovarin (CBGV), fiche réactif","pmid":null,"doi":null,"url":"https://www.medchemexpress.com/cannabigerovarin.html"}],"meta":{"slug":"cbgv","url":"https://es.phytogrammes.com/wiki/cbgv","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}