{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"KXKOBIRSQLNUPS-UHFFFAOYSA-N","prefName":"Ácido cannabinólico","symbol":"CBNA","iupacName":null,"aliases":["CBN-A","Cannabinolic acid"],"cas":"2808-39-1","pubchemCid":"3081990","chebiId":null,"smiles":"CCCCCC1=CC2=C(C3=C(C=CC(=C3)C)C(O2)(C)C)C(=C1C(=O)O)O","molecularFormula":"C22H26O4","molecularWeight":354.44,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/3081990"}},"classification":{"family":"mineur","familyLabel":"Fitocannabinoide menor","origin":"natural","originLabel":"Naturel","structuralClassFr":null},"originSynthesis":{"heading":"Vía biosintética","summaryFr":"Oxidación aerobia progresiva del THCA → CBNA en las flores envejecidas; después descarboxilación térmica → CBN","originNote":"Planta (ácido oxidado)","discovered":"1969"},"pharmacology":{"summaryFr":"El CBNA es el ácido precursor del CBN - resultado de la oxidación aerobia progresiva del THCA en las flores envejecidas. Caracterizado por Mechoulam (1969). No psicótropo. Francia: la **Decisión ANSM del 3 de junio de 2024** modifica la **Decisión ANSM del 22 de mayo de 2024** para **excluir explícitamente el CBN y el CBNA** de la cláusula benzo[c]cromeno - autorización explícita de extracción / comercialización como aislado. Nicho comercial emergente: aceites y complementos llamados « raw CBN ». Ninguna dosis humana caracterizada - datos animales / in vitro únicamente.","receptorSummaryFr":"Afinidad CB1/CB2 modesta; interés principalmente quimiotaxonómico","binding":[{"target":"CB1","efficacy":"partial_agonist","relativeActivity":20,"reported":null,"confidence":"low"},{"target":"CB2","efficacy":"partial_agonist","relativeActivity":30,"reported":null,"confidence":"low"}],"references":[]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":50},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":30},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":60},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":25},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":15}],"doseRanges":null,"humanDataCharacterised":true},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":false,"bannerTextFr":null,"toxicologyFr":null},"legal":{"scheduleStatus":"industrial-exempt","scheduleLabel":"Excepción del cáñamo","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No listado","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Explícitamente EXCLUIDO del régimen de estupefacientes (Decisión ANSM 03/06/2024)","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[],"meta":{"slug":"cbna","url":"https://es.phytogrammes.com/wiki/cbna","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":70,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}