{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"SSQJFGMEZBFMNV-WOJBJXKFSA-N","prefName":"HU-210 ((-)-11-hidroxi-Δ8-THC-DMH)","symbol":"HU-210","iupacName":null,"aliases":["HU210","(6aR,10aR)-9-(hydroxymethyl)-3-(2-methyloctan-2-yl)-..."],"cas":"112830-95-2","pubchemCid":"9821569","chebiId":null,"smiles":"CCCCCCC(C)(C)C1=CC(=C2[C@@H]3CC(=CC[C@H]3C(OC2=C1)(C)C)CO)O","molecularFormula":"C25H38O3","molecularWeight":386.57,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/9821569"}},"classification":{"family":"scra","familyLabel":"Cannabinoide sintético (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origen (investigación farmacéutica → mercado ilícito)","summaryFr":"Análogo 1,1-dimetilheptil-11-hidroxi-Δ8-THC obtenido por síntesis orgánica (1988)","originNote":"Universidad Hebrea de Jerusalén (Mechoulam)","discovered":"1988"},"pharmacology":{"summaryFr":"HU-210 es el cannabinoide de referencia del laboratorio Mechoulam (Universidad Hebrea) - sintetizado en 1988 (Mechoulam, Lander, Breuer & Zahalka). Modificación 1,1-dimetilheptil + 11-hidroxi de Δ8-THC: Ki = 0,061 nM (CB1, cerebro de rata) - agonista completo. Detectado brevemente en mezclas « Spice » incautadas en 2008-2009, pero rápidamente sustituido por los SCRA menos costosos de sintetizar. Francia: inscrito nominalmente en el Anexo IV por el **arrêté (orden ministerial) del 24 de febrero de 2009** (NOR SASP0900303A). UE: Decisión del Consejo **2009/206/JAI**.","receptorSummaryFr":"Agonista completo CB1 ultrapotente (Ki ≈ 0,061 nM; ≈ 100–800× THC según el ensayo)","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":100,"reported":"Ki ≈ 0,061 nM","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":95,"reported":"Ki ≈ 0,52 nM","confidence":"medium"}],"references":[{"label":"Mechoulam · Experientia 1988","pmid":"2832202","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/2832202/"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":25},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":10},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":60},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":60},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":99}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"controlled-named","scheduleLabel":"Estupefaciente: listado nominalmente","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"Decisión del Consejo 2009/206/JAI","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Estupefaciente inscrito nominalmente","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Mechoulam · Experientia 1988","pmid":"2832202","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/2832202/"}],"meta":{"slug":"hu-210","url":"https://es.phytogrammes.com/wiki/hu-210","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}