{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"SRJKCVHWIDFUBO-HXUWFJFHSA-N","prefName":"MDMB-CHMICA","symbol":"MDMB-CHMICA","iupacName":"methyl (S)-2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate","aliases":["MDMB-CHMINACA precursor name (incorrect)"],"cas":"1971007-95-0","pubchemCid":"125181404","chebiId":null,"smiles":"CC(C)(C)[C@@H](C(=O)OC)NC(=O)C1=CN(C2=CC=CC=C21)CC3CCCCC3","molecularFormula":"C23H32N2O3","molecularWeight":384.51,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/125181404"}},"classification":{"family":"scra","familyLabel":"Cannabinoide sintético (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origen (investigación farmacéutica → mercado ilícito)","summaryFr":"Indol-3-carboxamida con cabeza tert-leucinato metil-éster y cadena ciclohexilmetilo; concebido para escapar a las cláusulas indol-naftoílo","originNote":"Mercado ilícito (origen académico desconocido)","discovered":"2014"},"pharmacology":{"summaryFr":"El MDMB-CHMICA es un indol-3-carboxamida (cabeza L-tert-leucinato metil éster; cola ciclohexilmetilo) caracterizado por Banister et al. (ACS Chem Neurosci 2016, PMID 27421060): EC50 CB1 = 0,26 nM (beta-arrestina) - agonista completo ultrapotente. La evaluación de riesgos de la EUDA de 2016 documentó ≥ 25 muertes en Europa (UK 18, Bélgica, Hungría, Polonia, Alemania) entre 2014-2016. Decisión de ejecución (UE) **2017/369** de 27 de febrero de 2017 (CELEX 32017D0369): control obligatorio en toda la UE. Francia: **Arrêté (orden ministerial) del 31 de marzo de 2017** (NOR AFSP1710288A) - incluido en el anexo IV del arrêté del 22 de febrero de 1990.","receptorSummaryFr":"Agonista completo CB1 (EC50 ≈ 0,26 nM beta-arrestina) - entre los SCRA más potentes documentados","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":99,"reported":"EC50 ≈ 0,26 nM","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":90,"reported":null,"confidence":"low"}],"references":[{"label":"Banister · ACS Chem Neurosci 2016","pmid":"27421060","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/27421060/"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":25},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":15},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":60},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":50},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":98}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"controlled-named","scheduleLabel":"Estupefaciente: listado nominalmente","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"Decisión de ejecución (UE) 2017/369 (CELEX 32017D0369)","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Estupefaciente listado nominalmente (anexo IV)","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Banister · ACS Chem Neurosci 2016","pmid":"27421060","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/27421060/"}],"meta":{"slug":"mdmb-chmica","url":"https://es.phytogrammes.com/wiki/mdmb-chmica","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}