{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"DEWSJDIJFWQLOA-RTBURBONSA-N","prefName":"Acetato de THC-O (acetato de Δ9-tetrahidrocannabinol)","symbol":"THC-O","iupacName":"(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-yl acetate","aliases":["THC-O-A","THC acetate","ATHC"],"cas":"23132-17-4","pubchemCid":"198013","chebiId":null,"smiles":"CCCCCC1=CC2=C([C@@H]3C=C(CC[C@H]3C(O2)(C)C)C)C(=C1)OC(=O)C","molecularFormula":"C23H32O3","molecularWeight":356.5,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/198013"}},"classification":{"family":"semisynthetique","familyLabel":"Cannabinoide semisintético","origin":"semisynthetic","originLabel":"Semi-synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Vía de obtención (proceso químico)","summaryFr":"Acetilación del hidroxilo fenólico del Δ9-THC (anhídrido acético en medio piridina) - producto profármaco (el THC se libera por hidrólisis hepática)","originNote":"Semisíntesis (acetilación de THC)","discovered":"1949"},"pharmacology":{"summaryFr":"El acetato de THC-O (Adams, JACS 1949) es el éster acetato del Δ9-THC sobre el hidroxilo fenólico. Profármaco: se hidroliza en THC activo tras la inhalación o la ingestión, lo que explica la latencia de aparición (≈ 30-45 min) y el efecto « más fuerte » subjetivo (~ 3× THC según los usuarios). Punto crítico: en vapeo, el compuesto sufre una pirólisis parcial que produce **cetena** (ketene, OC=CH₂) - gas potentemente irritante pulmonar asociado al síndrome EVALI (Munger et al., Chem Res Toxicol 2023, PMID 37449873). Francia: captado por la **Decisión de la ANSM del 22 de mayo de 2024** (cláusula benzo[c]cromeno).","receptorSummaryFr":"El propio THC-O tiene una afinidad CB1 modesta; efecto mediado principalmente por hidrólisis en THC activo (profármaco)","binding":[{"target":"CB1","efficacy":"partial_agonist","relativeActivity":60,"reported":"via hydrolyse → THC","confidence":"medium"},{"target":"CB2","efficacy":"partial_agonist","relativeActivity":45,"reported":null,"confidence":"low"}],"references":[{"label":"Munger · Chem Res Toxicol 2023","pmid":"37449873","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/37449873/"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":50},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":25},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":75},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":80},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":90}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"controlled-clause","scheduleLabel":"Estupefaciente: cláusula genérica","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"Régimen cannabis en la mayoría de los Estados miembros","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Estupefaciente: cláusula genérica benzo[c]cromeno (Decisión de la ANSM 22/05/2024)","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Munger · Chem Res Toxicol 2023","pmid":"37449873","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/37449873/"}],"meta":{"slug":"thc-o","url":"https://es.phytogrammes.com/wiki/thc-o","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}