{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":null,"prefName":"Tetrahidrocannabivarina","symbol":"THCV","iupacName":null,"aliases":["Tetrahydrocannabivarine","THC-V"],"cas":"31262-37-0","pubchemCid":"93147","chebiId":null,"smiles":"CCCC1=CC(=C2[C@@H]3C=C(CC[C@H]3C(OC2=C1)(C)C)C)O","molecularFormula":"C19H26O2","molecularWeight":null,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/93147"}},"classification":{"family":"mineur","familyLabel":"Fitocannabinoide menor","origin":"natural","originLabel":"Naturel","structuralClassFr":null},"originSynthesis":{"heading":"Vía biosintética","summaryFr":"Variante propílica del THC (cadena propilo en lugar de pentilo) - surgida de la vía biosintética CBGVA → THCVA","originNote":"Planta","discovered":"1973"},"pharmacology":{"summaryFr":"Variante propílica del THC, donde la cadena pentilo se acorta a propilo (tres carbonos en lugar de cinco). Esta modificación estructural invierte parcialmente el efecto sobre el apetito: a dosis baja, el THCV bloquea CB1 y corta la sensación de hambre, lo contrario exacto del THC. A dosis alta, se vuelve él mismo ligeramente psicótropo. Presente sobre todo en los quimiotipos de origen africano (Sudáfrica, Malawi). Investigaciones en curso sobre su interés en la regulación glucémica (ensayos abiertos sobre la resistencia a la insulina) y en la dependencia nicotínica. Para Phytogrammes, sirve de complemento estratégico en determinados perfiles diurnos.","receptorSummaryFr":"Antagonista CB1 a dosis baja, agonista parcial CB1 a dosis alta, agonista CB2","binding":[{"target":"CB1 (faible dose)","efficacy":"antagonist","relativeActivity":60,"reported":null,"confidence":"low"},{"target":"CB1 (forte dose)","efficacy":"partial_agonist","relativeActivity":45,"reported":null,"confidence":"low"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":65,"reported":null,"confidence":"low"}],"references":[]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calma","description":"Relajación del cuerpo y de la mente; menos ruido mental, sin somnolencia marcada.","intensity":30},{"key":"focus","label":"Claridad","description":"Atención sostenida y pensamiento claro; lucidez funcional, sin euforia.","intensity":80},{"key":"sleep","label":"Sueño","description":"Efecto sedante: favorece la conciliación del sueño y la continuidad del sueño profundo.","intensity":15},{"key":"appetite","label":"Apetito","description":"Estimulación del hambre y de la apreciación gustativa (efecto «munchies»).","intensity":5},{"key":"uplift","label":"High","description":"Euforia e intensidad sensorial; percepción del tiempo y del espacio modificada.","intensity":70}],"doseRanges":null,"humanDataCharacterised":true},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":false,"bannerTextFr":null,"toxicologyFr":null},"legal":{"scheduleStatus":"industrial-exempt","scheduleLabel":"Excepción del cáñamo","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"THC total < 0,3 %","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Marco de derivado del THC - sujeto al umbral del 0,3 %","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[],"meta":{"slug":"thcv","url":"https://es.phytogrammes.com/wiki/thcv","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"low","dataCompletenessPct":70,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}